Effects of the New Anti-Ulcer Drug Ecabet Sodium (TA-2711) on Pepsin Activity I. Inactivation of Enzyme Protein

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Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. I. Inactivation of enzyme protein.

To investigate the mechanism of the anti-peptic action of ecabet sodium (TA-2711) observed in pylorous-ligated rats, effects of this drug on the peptic activity of rat gastric juice, purified hog pepsin and pepsinogen were studied in vitro. After incubation with or without ecabet at acidic pH, the reaction mixture was centrifuged, and the peptic activity of the supernatant was measured. Ecabet ...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1993

ISSN: 0021-5198

DOI: 10.1254/jjp.61.333